業績 -発 表 学 術 論 文-


1      Effect of a traditional Chinese herbal medicine, Ren-Shen-Yang-Rong-Tang (Japanese name: Ninjin-Youei-To), on oligodendrocyte precursor cells from aged-rat brain.

Kobayashi J, Seiwa C, Sakai T, Gotoh M, Komatsu Y, Yamamoto M, Fukutake M, Matsuno K, Sakurai Y, Kawano Y, Asou H.
Int Immunopharmacol. 2003 Jul;3(7):1027-39.

 

2      Changes of materials that scavenge 1,1-diphenyl-2-picrylhydrazyl radicals in plasma by per-oral administration of Kampo medicine, Ninjin-yoei-to in rats.

Egashira T, Takayama F, Komatsu Y.
J Pharm Pharmacol. 2003 Mar;55(3):367-71.

 

3      General pharmacological properties of Sho-seiryu-to (TJ-19) extracts.
Amagaya S, Iizuka A, Makino B, Kubo M, Komatsu Y, Cheng FC, Ruo TI, Itoh T, Terasawa K.

Phytomedicine. 2001 Sep;8(5):338-47

 

4      Acidic polysaccharides from rhizomes of Atractylodes lancea as protective principle in Candida-lnfected mice.

Inagaki N, Komatsu Y, Sasaki H, Kiyohara H, Yamada H, Ishibashi H, Tansho S, Yamaguchi H, Abe S.
Planta Med. 2001 Jul;67(5):428-31.

 

5      Acidic polysaccharides from rhizomes of Atractylodes lancea as protective principle in Candida-lnfected mice.

Inagaki N, Komatsu Y, Sasaki H, Kiyohara H, Yamada H, Ishibashi H, Tansho S, Yamaguchi H, Abe S.
Planta Med. 2001 Jul;67(5):428-31.

 

6      Effect of Choto-san, a Kampo medicine, on the cerebral blood flow autoregulation in spontaneously hypertensive rats.
Sugimoto A, Goto K, Ishige A, Komatsu Y, Miyamoto KI.

Jpn J Pharmacol. 2000 Jun;83(2):135-42.

 

7      Protective effect of oral administration of several traditional Kampo-medicines on lethal Candida infection in immunosuppressed mice

Abe S, Ishibashi H, Tansho S, Hanazawa R Komatsu Y, Yamaguchi H..
Nippon Ishinkin Gakkai Zasshi. 2000;41(2):115-9. Japanese.

 

8      Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice.
Yamamoto M, Miura N, Ohtake N, Amagaya S, Ishige A, Sasaki H, Komatsu Y, Fukuda K, Ito T, Terasawa K.

Gastroenterology. 2000 Feb;118(2):380-9.

 

9      Antioxidative effects of Choi-oki-to and its ability to inhibit the progression of atheroma in KHC rabbits.

Iizuka A, Iijima OT, Kondo K, Matsumoto A, Itakura H, Yoshie F, Komatsu Y, Takeda H, Matsumiya T.
J Atheroscler Thromb. 2000;6(2):49-54

 

10   Effects of 9 Kampo medicines clinically used in hypertension on hemodynamic changes induced by theophylline in rats.

Sanae F, Komatsu Y, Amagaya S, Chisaki K, Hayashi H.
Biol Pharm Bull. 2000 Jun;23(6):762-5.

 

11   Protective effect of oral administration of several traditional Kampo-medicines   on lethal Candida infection in immunosuppressed mice]

Abe S, Ishibashi H, Tansho S, Hanazawa R, Komatsu Y, Yamaguchi H.
Nippon Ishinkin Gakkai Zasshi. 2000;41(2):115-9. Japanese.

 

12   Modulation of lung local immune responses by oral administration of a herbal medicine Sho-saiko-to.

Ohtake N, Suzuki R, Daikuhara H, Nakai Y, Yamamoto M, Amagaya S, Ishige A, Sasaki H, Komatsu Y, Fukuda K, Hayashi S.
Int J Immunopharmacol. 2000 Jun;22(6):419-30.

 

13   HPLC analysis of juzen-taiho-to and its variant formulations and their antimetastatic efficacies.
Saiki I, Yamaura T, Ohnishi Y, Hayakawa Y, Komatsu Y, Nunome S.

   Chem Pharm Bull (Tokyo). 1999 Aug;47(8):1170-4.  

 

14   Monitoring of radical scavenging activity of peroral administration of the Kampo medicine Sho-saiko-to in rats.

Egashira T, Takayama F, Yamanaka Y, , Komatsu Y, .
Jpn J Pharmacol. 1999 Aug;80(4):379-82.

 

15   Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components.

Kase Y, Saitoh K, Makino B, Hashimoto K, Ishige A, , Komatsu Y,
Phytother Res. 1999 Sep;13(6):468-73.

 

16   Effects of Sho-seiryu-to on experimental allergic rhinitis in guinea pigs.

Sakaguchi M, Mase A, Ikeda Y, Iizuka A, Imamura S, , Komatsu Y, Ukai K, Sakakura Y.
Methods Find Exp Clin Pharmacol. 1999 May; 21(4):303-8.

 

17   Effect of Choto-san, a kampo medicine, on impairment of passive avoidance performance in mice.
Yuzurihara M, Goto K, Sugimoto A, Ishige A, , Komatsu Y, Shimada Y, Terasawa K.

Phytother Res. 1999 May; 13(3):233-5.

 

18    Protection of immunosuppressed mice from lethal Candida infection by oral administration of a kampo medicine, hochu-ekki-to.

Abe S, Tansho S, Ishibashi H, Akagawa G, Komatsu Y, Yamaguchi H.
Immunopharmacol Immunotoxicol. 1999 May; 21(2):331-42.

 

  15  Effects of Dai-kenchu-to on intestinal obstruction following laparotomy.

  Hayakawa T, Kase Y, Saito K, Hashimoto K, Ishige A,  Komatsu Y, Sasaki H.

J Smooth Muscle Res. 1999 Apr; 35(2):47-54.

 

16   Effects of Saiko-ka-ryukotsu-borei-to, a Japanese Kampo medicine, on tachycardia and central nervous system stimulation induced by theophylline in rats and mice.
Sanae F, Hayashi H, Chisaki K, Komatsu Y, 

Jpn J Pharmacol. 1999 Mar; 79(3):283-8.

 

17   Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice.

Suzuki Y, Goto K, Ishige A, , Komatsu Y,, Kamei J.

Jpn J Pharmacol. 1999 Feb; 79(2):169-75.

 

18   Inhibition by dexamethasone of transforming growth factor beta1-induced apoptosis in rat hepatoma cells: a possible association with Bcl-xL induction.
Yamamoto M, Fukuda K, Miura N, Suzuki R, Kido T, Komatsu Y.

Hepatology. 1998 Apr; 27(4):959-66. PMID: 9537434

 

19    Requirement of the glycosyl parts in platycodin D to stimulate pancreatic exocrine secretion.

Ida Y, Hirai Y, Kajimoto T, Shingu K, Miura T, Kuwahara N, Taguchi S, Sasaki K, Kuroiwa Y, Yamamoto T, Arai I, Amagaya S, Komatsu Y.
Bioorg Med Chem Lett. 1998 Aug 18;8(16): 2209-12.

 

20    Protective effect of oral administration of a traditional medicine, Juzen-Taiho-To, and its components on lethal Candida albicans infection in immunosuppressed mice.

Abe S, Tansho S, Ishibashi H, Inagaki N, Komatsu Y, Yamaguchi H.
Immunopharmacol Immunotoxicol. 1998 Aug; 20(3):421-31

 

 

21    Effect of Gosha-jinki-gan, a Kampo medicine, on enhanced platelet aggregation in streptozotocin-induced diabetic rats.

Suzuki Y, Goto K, Ishige A, Komatsu Y, Kamei J.
Jpn J Pharmacol. 1998 Sep; 8(1):87-91.

 

22    Protective effect of oral administration of a traditional medicine, Juzen-Taiho-To, and its components on lethal Candida albicans infection in immunosuppressed mice.

Abe S, Tansho S, Ishibashi H, Inagaki N, Komatsu Y, Yamaguchi H.
Immunopharmacol Immunotoxicol. 1998 Aug; 20(3):421-31.

 

23    Effects of gosha-jinki-gan, a kampo medicine, on peripheral tissue blood flow   in streptozotocin-induced diabetic rats.

Suzuki Y, Goto K, Ishige A, Komatsu Y, Kamei J.
Methods Find Exp Clin Pharmacol. 1998 May; 20(4):321-8.

 

24   Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-to constituents.
Onishi Y, Yamaura T, Tauchi K, Sakamoto T, Tsukada K, Nunome S, Komatsu Y,, Saiki I.

Biol Pharm Bull. 1998 Jul; 21(7):761-5.

 

    25  Anti-inflamm.atory effects of mao-bushi-saishin-to in mice and rats

Ikeda Y, Iijima OT, Iizuka A, Ishige A, Amagaya , Komatsu Y, Okada M, Abe C, Fujihira E.

Am J Chin Med. 1998; 26(2):171-9.

 

26   Oral administration of a Kampo (Japanese herbal) medicine Juzen-taiho-to inhibits liver metastasis of colon 26-L5 carcinoma cells.

Ohnishi Y, Fujii H, Hayakawa Y, Sakukawa R, Yamaura T, Sakamoto T, Tsukada K, Fujimaki M, Nunome S, Komatsu Y, Saiki I.
Jpn J Cancer Res. 1998 Feb; 89(2):206-13.

 

27   Inhibition of thymocyte apoptosis by berberine.

Miura N, Yamamoto M, Ueki T, Kitani T, Fukuda K, Komatsu Y,
Biochem Pharmacol. 1997 May 9; 53(9):1315-22

 

28    New nortriterpenoid isolated from anti rheumatoid arthritic- plant, Tripterygium wilfordii, modulates tumor growthand neovascul arization.
Ushiro S, Ono M, Nakayama J, Fujiwara T, Komatsu Y, Sugimachi K, Kuwano M.

Int J Cancer. 1997 Aug 7; 72(4):657-63

 

29   Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to.

Hisha H, Yamada H, Sakurai MH, Kiyohara H, Li Y, Yu C, Takemoto N, Kawamura H, Yamaura K, Shinohara S, Komatsu Y, Aburada M, Ikehara S.
Blood. 1997 Aug 1; 90(3):1022-30..

 

30   . Further pharmacological study on Sho-seiryu-to as an antiallergic.

    Sakaguchi M, Mase A, Iizuka A, Yuzurihara M, Ishige A, Amagaya S, Komatsu Y, Takeda H, Matsumiya T.

Methods Find Exp Clin Pharmacol. 1997 Dec;19(10):707-13

 

31    Effects of choreito and takushya consumption on in vitro and in vivo struvite

   solubility in cat urine.

Buffington CA, Blaisdell JL, Komatsu Y, Kawase K.
Am J Vet Res. 1997 Feb; 58(2):150-2.

 

    32  Effects of choreito consumption on urine variables of healthy cats fed a magnesium-supplemented commercial diet.

Buffington CA, Blaisdell JL, Kawase K, Komatsu Y,

Am J Vet Res. 1997 Feb; 58(2):146-9.

 

32   Effects of Saiko-ka-ryukotsu-borei-to on irritable characteristics in El mice.

    Iizuka S, Ishige , Komatsu Y, Matsumiya T, Tsuji M, Takeda H.

Methods Find Exp Clin Pharmacol. 1998 Jan-Feb; 20(1):19-26.

 

33   Effects of Hange-shashin-to on cholera toxin-induced fluid secretion in the small intestine of rats.

Kase Y, Saitoh K, Yuzurihara M, Ishige A, Komatsu Y,
Biol Pharm Bull. 1998 Feb; 21(2):117-20.

 

34   Preventive effects of Hange-shashin-to on irinotecan hydrochloride-caused diarrhea and its relevance to the colonic prostaglandin E2 and water absorption in the rat.

Kase Y, Hayakawa T, Aburada M, Komatsu Y, Kamataki T.
Jpn J Pharmacol. 1997 Dec; 75(4):407-13.

 

   35  Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats.

Arai , Komatsu Y, Hirai Y, Shingu K, Ida Y, Yamaura H, Yamamoto T, Kuroiwa Y, Sasaki K, Taguchi S.

Planta Med. 1997 Oct; 63(5):419-24.

 

36   harmacological characteristics of Sho-seiryu-to, an antiallergic Kampo medicine without effects on histamine H1 receptors and muscarinic cholinergic system in the brain.

Sakaguchi M, Iizuka A, Yuzurihara M, Ishige A, Komatsu Y, Matsumiya T, Takeda H.
Methods Find Exp Clin Pharmacol. 1996 Jan-Feb; 18(1):41-7.

 

37   The effect of herbal medicines on the immunodeficient animals by injecting cancer chemotherapeutic agent-special reference to age related recovery of the function]

Li AL, Komatsu Y, Ono Y, Nakatani F, Nakashima K, Yamaguchi N.
Kansenshogaku Zasshi. 1996 Jul; 70(7):717-26. Japanese.

38    Phenolic nortriterpene demethylzeylasteral: a new immunosuppressive     component of Tripterygium Wilfordii Hook f.

Tamaki T, Kawamura A, Komatsu Y, Kawamura H, Maruyama H, Morota T.
Transplant Proc. 1996 Jun; 28(3):1379-80. No abstract available.

 

39    Protective effect of oral administration of a pectic polysaccharide fraction from a Kampo (Japanese herbal) medicine "Juzen-Taiho-To" on adverse effects of cis-diaminedichloroplatinum.
Kiyohara H, Matsumoto T, Komatsu Y, Yamada H.

Planta Med. 1995 Dec; 61(6):531-34.

 

40     Effect of oral administration of a pectic polysaccharide fraction from a kampo (Japanese herbal) medicine "juzen-taiho-to" on antibody response of mice.
 
Kiyohara H, Matsumoto T, Takemoto N, Kawamura , Komatsu Y, Yamada H.

Planta Med. 1995 Oct; 61(5):429-34.

 

41    関節炎の質四系の関節炎モデルにおける早期病変の解析.

安部千之、 菊川忠裕、 小松靖弘 後藤 真、 藤平栄一、 平野伸一. 

  炎症. 15: 395-399, 1995

 

42    A novel type of B-cell mitogen isolated from juzen-taiho-to (TJ-48), a Japanese traditional medicine.
Takemoto N, Kiyohara H, Maruyama H, Komatsu Y, Yamada H, Kawamura H.

Int J Immunopharmacol. 1994 Nov;16(11):919-29.

   

43    Antitumour Effect of Juzenntaiho-to, a Kampo Medicine, combined with surgical Excision for Transplanted Meth-A Fibrosarcoma

Maruyama H, Takemoto N, Maruyama N, Komatsu Y., Kawamura H.

        Int. J. Immunotherapy 1993 IX (2) 117-125

 

44    Mitogenic and complement activating activities of the herbal components of juzen-taiho-to.
Yamada H, Kiyohara H, Takemoto N, Zhao JF, Kawamura H, Komatsu Y, Cyong JC, Aburada M, Hosoya E.

Planta Med. 1992 Apr;58(2):166-70.

  

45   Induction of human microvascular endothelial tubular morphogenesis by human keratinocytes: involvement of transforming growth factor-alpha.
Ono M, Okamura K, Nakayama Y, Tomita M, Sato Y, Komatsu Y, Kuwano M.

Biochem Biophys Res Commun. 1992 Dec 15;189 (2):601-9

.

46    Effects of medicinal plants on hemopoietic cells.
Ikehara S, Kawamura H, Komatsu Y, Yamada H, Hisha H, Yasumizu R, Ohnishi-Inoue Y, Kiyohara H, Hirano M, Aburada M, et al.

Adv Exp Med Biol. 1992;319: 319-30 

 

47    Characterization of mitogenic pectic polysaccharides from kampo (Japanese herbal) medicine "juzen-taiho-to".
Kiyohara H, Takemoto N, Komatsu Y, Kawamura H, Hosoya E, Yamada H.

Planta Med. 1991 Jun;57 (3):254-9

 

48    Fractionation and characterization of mitogenic and anti-complementary active fractions from kampo (Japanese Herbal) medicine "juzen-taiho-to".
Yamada H, Kiyohara H, Cyong JC, Takemoto , Komatsu Y, Kawamura H, Aburada M, Hosoya E.

Planta Med. 1990 Aug; 56(4): 386-91.

 

    48  十全大補湯の免疫系に対する作用

武元則人、丸山博文、川村秀樹、小松靖弘、油田正樹、細谷英吉、

炎症. , 1989; 9(2): 137-140

 

49 十全大補湯の免疫系に対する作用

武元則人、川村秀樹、丸山博文、小松靖弘、油田正樹、細谷英吉、

炎症. , 1989; 9(1): 49-52

 

50 十全大補湯の食細胞に及ぼす影響

丸山博文、川村秀樹、武元則人、小松靖弘、油田正樹、細谷英吉、

炎症. , 1988; 8(5): 461-465

 

51    全大補湯の免疫応答に及ぼす影響

小松靖弘、武元則人、丸山博文、土屋博司、油田正樹、細谷英吉、篠原精一、浜田一

炎症. , 1986; 6(4): 405-408

 

52   Influenza virus A/Kumamoto haemagglutinin induces type I, III, and IV hypersensitivity in mice.
Abe C, Ono N, Nishimura , Komatsu Y, Taki S, Hamuro J.

Int J Tissue React. 1985;7(4):249-53.

 

53  The segregation of specific clones of cytotoxic lymphocytes in an in vitro  

primary response against influenza virus.
 Komatsu Y,  Nawa Y, Marbrook J.

Immunol Lett. 1982;5(6):351-5.

 

54  Clones of cytotoxic lymphocytes can recognise uninfected cells in a primary response against influenza virus.

Komatsu Y,  Nawa Y, Bellamy AR, Marbrook J.
Nature. 1978 Aug 24;274(5673):802-4.